Journal
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
Volume 32, Issue 9, Pages 1299-1304Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10815-015-0515-1
Keywords
Obesity; Blastocyst; IVF outcome; Metabolic dysfunction; Embryo quality
Ask authors/readers for more resources
The aim of this study is to investigate the effect of female BMI and metabolic dysfunction on blastocyst formation rate. This was a retrospective cohort study that was performed in an academic center for reproductive medicine. Patients who were normal weight, overweight with metabolic dysfunction, or obese who had a parts per thousand yen6 oocytes retrieved in a fresh IVF cycle were included in the study. The blastocyst formation rate was calculated from the number of a parts per thousand yen5 cell embryos on day 3 observed in culture until day 5 or day 6. Only good quality blastocysts were included in the calculation as defined by a morphologic grade of 3BB or better. The blastocyst formation rate was significantly better in the normal-weight controls versus overweight/obese patients (57.2 versus 43.6 %, p < 0.007). There was no difference in blastocyst formation between the patients with a BMI 25-29.9 kg/m(2) with metabolic dysfunction and those with a BMI a parts per thousand yen30 kg/m(2). The maternal metabolic environment has a significant impact on embryo quality as measured by blastocyst formation. A decreased blastocyst formation rate is likely a significant contributor to poorer reproductive outcomes in overweight and obese women with infertility.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available