Journal
AUTOPHAGY
Volume 7, Issue 6, Pages 664-665Publisher
LANDES BIOSCIENCE
DOI: 10.4161/auto.7.6.15448
Keywords
presenilin; autophagy; gamma-secretase; lysosome; Alzheimer disease; calcium
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Degradation through the lysosome involves careful orchestration of numerous molecular players in concert. Many of these key molecular players remain to be identified. We find that wild-type presenilins play a key role in degradation through the autophagy-lysosome system by modulating either fusion of autophagosomes to lysosomes or lysosome function.
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