Journal
AUTOPHAGY
Volume 6, Issue 1, Pages 166-167Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.6.1.10624
Keywords
influenza virus; matrix protein 2; apoptosis; Atg6/Beclin 1; autophagosome stabilization
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Funding
- NATIONAL CANCER INSTITUTE [R01CA108609, R01CA101741] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA108609, R01 CA101741] Funding Source: Medline
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We have recently characterized that influenza A virus blocks autophagosome degradation via its matrix protein 2. Matrix protein 2 seems to achieve this macroautophagy inhibition not by its well-characterized proton channel function, but possibly due to its binding to Atg6/Beclin 1, thereby enhancing the death of its host cell. Here we discuss several viruses that now have been described to compromise macroautophagy via binding to Atg6/Beclin 1 with different outcomes for their replication, and how interaction with one and the same protein could inhibit autophagosome generation or degradation.
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