Journal
AUTOPHAGY
Volume 6, Issue 5, Pages 672-673Publisher
LANDES BIOSCIENCE
DOI: 10.4161/auto.6.5.12509
Keywords
ATM; cytoplasm; ROS; mTOR; DNA damages
Categories
Funding
- NCI NIH HHS [R01 CA63613, R01 CA063613-13, P50 CA098258, P30 CA016672, P30 CA016672-27, R01 CA143811, CA 16672, R01 CA143811-02, R01 CA108941, R01 CA063613] Funding Source: Medline
- NIEHS NIH HHS [P30 ES007784, ES007784, P30 ES007784-12] Funding Source: Medline
- NIGMS NIH HHS [R01 GM062694] Funding Source: Medline
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The link between reactive oxygen species (ROS) and induction of autophagy has been well documented, but the molecular mechanisms regulating this phenomenon are only beginning to be elucidated. Autophagy is now being appreciated as an integral part of the cellular response to many diverse types of cellular stresses including nutrient deprivation, hypoxia, oxidative stress, and DNA damage, and likely the mechanism(s) for each type of stress vary considerably. The cellular outcome of inducing autophagy in response to stress is also quite complex, and depends on many factors including cellular context, type and magnitude of stress.
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