Journal
AUTOPHAGY
Volume 6, Issue 2, Pages 278-280Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.6.2.10901
Keywords
autophagy; genetic screen; mitochondria; mitophagy; vacuole; yeast
Categories
Funding
- NIGMS NIH HHS [R01 GM053396, R01 GM053396-20, GM53396] Funding Source: Medline
Ask authors/readers for more resources
Mitochondria autophagy(mitophagy) is the process of selective degradation of mitochondria that has an important role in mitochondrial quality control. To gain insight into the molecular mechanism of mitophagy, we screened a yeast knockout library for strains that are defective in mitophagy. We found 32 strains that showed a complete or partial block of mitophagy. One of the genes identified, YLR356W, is required for mitophagy, but not for macroautophagy or other types of selective autophagy. The deletion of YLR356W partially inhibits mitophagy during starvation, whereas there is almost complete inhibition at post-log phase. Accordingly, we hypothesize that Ylr356w is required to detect or present aged or dysfunctional mitochondria when cells reach the post-log phase.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available