Journal
AUTOPHAGY
Volume 5, Issue 4, Pages 578-579Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.5.4.8367
Keywords
HPV16 E6/E7 oncoproteins; autophagy; metabolic stress; mTOR; p53; trophic sentinel pathway; cervical cancer
Categories
Funding
- PHS [R01CA081135]
- [T32CA00903]
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Normal human epithelial cells that express the human papillomavirus type 16 (HPV16) E7 oncoprotein show evidence of autophagy, and when deprived of growth factors they undergo cell death. We hypothesize that the process of autophagy renders such cells particularly vulnerable to cell death and suggest that autophagy induced as a consequence of uncontrolled proliferation and changes in metabolism may represent an Achilles' heel of human cancers and serve as a target for cancer therapy.
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