Journal
AUTOPHAGY
Volume 5, Issue 6, Pages 847-849Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.8824
Keywords
autophagy; aging; chronological life span; rapamycin; Saccharomyces cerevisiae
Categories
Funding
- NIH [AG023719]
Ask authors/readers for more resources
Rapamycin is an antibiotic that stimulates autophagy in a wide variety of eukaryotes, including the budding yeast Saccharomyces cerevisiae. Low concentrations of rapamycin extend yeast chronological life span (CLS). We have recently shown that autophagy is required for chronological longevity in yeast, which is attributable in part to a role for autophagy in amino acid homeostasis. We report herein that low concentrations of rapamycin stimulate macroautophagy during chronological aging and extend CLS.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available