Journal
AUTOPHAGY
Volume 5, Issue 8, Pages 1190-1193Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.5.8.10087
Keywords
autophagy flux; LC3; retinal pigment epithelium; lysosomes; age-related macular degeneration; aging
Categories
Funding
- Forsythe Foundation [1RO1EY019688]
- National Institutes of Health
- Research to Prevent Blindness
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Autophagy is a highly conserved housekeeping pathway that plays a critical role in the removal of aged or damaged intracellular organelles and their delivery to lysosomes for degradation.(1,2) 2 Autophagy begins with the formation of membranes, arising in part from the endoplasmic reticulum, that elongate and fuse engulfing cytoplasmic constituents into a classic double-membrane bound nascent autophagosome. These early autophagosomes undergo a stepwase maturation process to, form the late autophagosome or amphisome that ultimately fuses with a lysosome. Efficient autophagy is dependent on an equilibrium between the formation and elimination of autophagosomes; thus, a deficit in any part of this pathway will cause autophagic dysfunction. Autophagy plays a role in aging and age-related diseases.(1,2,7) However, few studies of autophagy in retinal disease have been reported.
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