Journal
AUTOPHAGY
Volume 5, Issue 5, Pages 725-726Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.5.5.8504
Keywords
mTORC1; mTOR; raptor; torin1; rapamycin resistance; rapamycin; autophagy; 4E-BP1; cap-dependent translation
Categories
Funding
- NCI NIH HHS [R01 CA129105, R01 CA129105-03] Funding Source: Medline
Ask authors/readers for more resources
Rapamycin is widely used as a complete inhibitor of the mTORC1 nutrient-sensitive signaling complex. Using a novel ATP-competitive inhibitor named Torin1, we have found that many mTORC1 functions that regulate cap-dependent translation and autophagy are resistant to inhibition by rapamycin.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
