Journal
AUTOPHAGY
Volume 5, Issue 3, Pages 434-435Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.5.3.7925
Keywords
amphisome; autophagy; dengue; endosome; replication; translation
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Amphisomes are preautolysosomal vacuoles formed upon the fusion of autophagosomes with endosomes, and as such represent a critical meeting point between endocytic and autophagic pathways. Dengue virus enters into susceptible cells by clathrin-mediated endocytosis, and colocalization of dengue markers with markers of both autophagic and endosomal vesicles demonstrates that amphisomes are a site of dengue virus replication and translation. This work links for the first time the processes of dengue virus entry and translation/replication, and allows for interpretation of the early part of the dengue virus life cycle in terms of a continual association with membranes of an endosomal-autophagosomal lineage.
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