Journal
AUTOPHAGY
Volume 5, Issue 1, Pages 93-95Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.5.1.7248
Keywords
apoptosis; autophagy; HSP70; iron; lysosomes; reactive oxygen species (ROS)
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Lysosomes contain most of the cell's supply of labile iron, which makes them sensitive to oxidative stress. To keep lysosomal labile iron at a minimum, a cellular strategy might be to autophagocytose iron-binding proteins that temporarily would chelate iron in a nonredox-active form. Previously we have shown that autophagy of metallothioneins, as well as of non-Fe-saturated ferritin, meets this goal. Here we add another stress-regulated protein to the list, namely HSP70.
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