Journal
AUTOPHAGY
Volume 5, Issue 3, Pages 314-320Publisher
LANDES BIOSCIENCE
DOI: 10.4161/auto.5.3.7888
Keywords
autophagy; autophagic cell death; NMR; Bcl-X-L; Bcl-2; inhibitor
Categories
Funding
- 973 Program [2009CB521703]
- National Science Foundation of China [30800172]
- 863 Program [2006AA020601]
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Inhibition of Bcl2 family proteins Bcl-X-L and Bcl-2 represents a promising drug development strategy for cancer treatment by triggering apoptosis in cancer cells. Here we report a novel Bcl-X-L inhibitor, Z36, which unexpectedly induces only autophagic cell death, but not apoptosis. This special property distinguishes Z36 from other previously reported Bd-X-L and Bcl-2 inhibitors that induce cancer cell death mainly through apoptosis, and makes Z36 an attractive molecular tool for studying the cellular regulation of autophagic cell death and apoptosis.
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