Journal
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Volume 45, Issue 5, Pages 697-699Publisher
MOSBY, INC
DOI: 10.1067/mjd.2001.117735
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Background. UVA1 radiation seems to be effective in morphea. CD34(+) dendritic cells are significantly decreased in lesional skin of morphea patients. Objective: We evaluated the therapeutic effectiveness of medium-close UVA1 phototherapy, in localized scleroderma and its effect in the number of dermal CD34(+) dendritic cells in skin biopsy specimens of these patients. Method: Patients were irradiated with UVA1 (30 J/cm(2)) 30 times. Dermal CD34(+) dendritic cells were counted before and after therapy. Results: There was clinical improvement after UVA1 irradiation. Dermal CD34(+) dendritic cells significantly increased after UVA1 irradiation. Conclusion: Medium-close UVA1 therapy is effective in the treatment of localized morphea, Effectiveness is associated with an increase in the number of CD34(+) dendritic cells in the dermis.
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