Journal
AUTOPHAGY
Volume 4, Issue 5, Pages 607-611Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.6397
Keywords
autophagy; TLR; phagocytosis; LC3; pathogen; phagosomal maturation; immunity
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Funding
- NCI NIH HHS [P01 CA069381, P01 CA069381-130010] Funding Source: Medline
- NIAID NIH HHS [R01 AI047891, R01 AI047891-10, R01 AI040646, R01 AI040646-11, R01 AI044828-11, R01 AI044828] Funding Source: Medline
- NIGMS NIH HHS [R01 GM052735-11, R01 GM052735] Funding Source: Medline
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Autophagy is a conserved pathway that sequesters cytoplasmic material and delivers it to lysosomes for degradation. Digestion of portions of the cell interior plays a key role in the recycling of nutrients, remodeling, and disposal of superfluous organelles. Along with its metabolic function, autophagy is an important mechanism for innate immunity against invading bacteria and other pathogens. Multicellular organisms seem to have exploited autophagy to eliminate intracellular pathogens that would otherwise grow in the cytoplasm. Surprisingly, autophagy is involved in the response to extracellular pathogens as well, following their engulfment by conventional phagocytosis. Possible links between these two forms of cellular eating represent a new dimension in host defense.
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