Journal
PLANTA MEDICA
Volume 67, Issue 8, Pages 685-694Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2001-18365
Keywords
terpenoids; Mycobacterium tuberculosis; antituberculosis; tuberculostatic; antimycobacterial
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Tuberculosis (TB), mainly caused by Mycobacterium tuberculosis, is the leading killer among all infectious diseases worldwide and is responsible for more than two million deaths annually. For over thirty years no antitubercular agents with new mechanisms of action have been developed. The recent increase in the number of multi-drug resistant clinical isolates of M. tuberculosis has created an urgent need for the discovery and development of new antituberculosis leads. This review covers recent reports on plant-derived terpenoids that have demonstrated moderate to high activity in in vitro bioassays against M. tuberculosis. In this review, mono-, sesqui-, di- and triterpenes, and sterols, their structural analogs and semisynthetic derivatives will be discussed, with particular emphasis on the structural features essential for antimycobacterial activity.
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