Journal
AUTOPHAGY
Volume 4, Issue 4, Pages 409-415Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.5638
Keywords
heart; ischemia; autophagy; reperfusion; apoptosis; AMPK; Beclin1
Categories
Funding
- NHLBI NIH HHS [R01 HL067724-09, HL73048, HL67727, HL67724, R01 HL067727-01, P01 HL069020-080007, HL69020, R01 HL033107, HL59139, P01 HL069020, P01 HL059139-060011, P01 HL059139-10, P01 HL059139, R01 HL067724] Funding Source: Medline
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Autophagy is an intracellular bulk degradation process whereby cytoplasmic proteins and organelles are degraded and recycled through lysosomes. In the heart, autophagy plays a homeostatic role at basal levels, and the absence of autophagy causes cardiac dysfunction and the development of cardiomyopathy. Autophagy is induced during myocardial ischemia and further enhanced by reperfusion. Although induction of autophagy during the ischemic phase is protective, further enhancement of autophagy during the reperfusion phase may induce cell death and appears to be detrimental. In this review we discuss the functional significance of autophagy and the underlying signaling mechanism in the heart during ischemia/reperfusion.
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