Journal
AUTOPHAGY
Volume 4, Issue 8, Pages 998-1008Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.6880
Keywords
HIV-1; autophagy; envelope glycoproteins; gp41; CXCR4; cell-to-cell fusion; syncytia; cell death; bystander cells
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Funding
- Centre National de la Recherche Scientifique (CNRS)
- SIDACTION
- Agence Nationale de Recherches Sur le SIDA (ANRS)
- [36600/06 FIPSE]
- [PI051504 FIS]
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Abbreviations: CHR, C-terminal heptad repeat; Env, HIV-1 envelope glycoproteins (gp 120 + gp41); Env.41.2, Env in which gp41 presents a mutation in the second amino acid of gp41 (gp41.2); Env.Delta t, Env in which the last 144 a.a. of the gp41 cytoplasmic tail were deleted (gp41.Delta t); ERK, extracellular signal regulated kinase; FP, fusion peptide; ICL, intracellular loop; ICLm, mutated intracellular loop; Jak, janus kinase; NHR, N-terminal heptad repeat, STAT signal transduction and activation of transcription; TEM, transmission electron microscopy; x4 CXCR4-using HIV-1 isolates; 6-HB, 6-helix bundle structure
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