Journal
FEBS LETTERS
Volume 507, Issue 3, Pages 357-361Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(01)03007-1
Keywords
Glut4; Glut1; lovastatin; cholesterol; isoprenoid; adipocyte
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Lovastatin treatment caused down-regulation of the insulin-responsive glucose transporter 4 (Glut4) and up-regulation of Glut1 in 3T3-L1 adipocytes. These changes in protein expression were associated with a marked inhibition of insulin-stimulated glucose transport. Lovastatin had no effect on cell cholesterol levels, but its effects were reversed by mevalonate, demonstrating that inhibition of isoprenoid biosynthesis causes insulin resistance in 3T3-L1 adipocytes. These findings support the notion that whole body insulin resistance may arise as a result of perturbations in general biochemical pathways, rather than primary defects in insulin signalling. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
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