4.8 Article

The plant alkaloid voacamine induces apoptosis-independent autophagic cell death on both sensitive and multidrug resistant human osteosarcoma cells

Journal

AUTOPHAGY
Volume 4, Issue 8, Pages 1020-1033

Publisher

TAYLOR & FRANCIS INC
DOI: 10.4161/auto.6952

Keywords

autophagy; voacamine; osteosarcoma cells; multidrug resistance; cell death

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Abbreviations: ATG, autophagy-related gene; AVOs, acidic vesicular organelles; BAF, bafilomycin A1; DAPI, 4', 6'-diamidine-2-phenylindole dihydrochloride; DOX, doxorubicin; FBS, fetal bovine serum; imps, intramembrane particles; LC3, microtubule-associated protein I (MAP1) light chain 3; MDC, monodansylcadaverine; MDR, multidrug resistance, PARP, poly (ADP-ribose) polymerase; PI, propidium iodide; PS, phosphatidylserine; SEM, scanning electron microscopy; TEM, transmission electron microscopy; VOA, voacamine; WM, worumannin; 3-MA, 3-methyladenine

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