Journal
CANCER LETTERS
Volume 173, Issue 1, Pages 15-20Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3835(01)00685-1
Keywords
epigallocatechin gallate; laminin; cell adhesion; green tea; melanoma
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We examined the effects of five kinds of green tea catechin on the adhesion of mouse melanoma B16 cells to laminin. (-)-Epigallocatechin gallate (EGCG) and (-)-epicatechin gallate in the culture medium were found to inhibit the cell adhesion. The adhesion to laminin pre-treated with EGCG was also impaired. Affinity chromatography revealed the binding affinity between laminin and EGCG. These data suggest that the inhibitory effect of EGCG on adhesion of melanoma cells to laminin is included in the mechanism(s) of previously reported metastasis inhibition elicited by EGCG and green tea infusion. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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