Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 18, Issue 1, Pages 59-64Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2015.1121853
Keywords
anti-inflammatory activity; structure elucidation; isolation; Dryopteris fragrans; Dryopteridaceae
Funding
- Beijing Natural Science Foundation [7144200]
- Beijing Municipal Science & Technology Commission [Z141100002214015]
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Phytochemical investigation on the aqueous extract from Dryopteris fragrans led to the isolation of one new chromone glycoside, frachromone C (1), and one new coumarin glycoside, dryofracoulin A (2), together with one known undulatoside A (3). Their structures were elucidated by a combination of 1D and 2D NMR, HRMS, and chemical analysis. Compounds 1-3 exhibited inhibition on nitric oxide production in lipopolysaccharide induced RAW 264.7 macrophages with their IC50 values of 45.8, 65.8, and 49.8 mu M, respectively.
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