Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 44, Issue 23, Pages 4011-4014Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm0109356
Keywords
-
Categories
Ask authors/readers for more resources
The design, synthesis, and rapid evaluation of a new class of acetylcholinesterase (AChE) inhibitors related to donepezil are reported. A molecular dynamics simulation of the complex between AChE and one representative compound of the series showed a possible inhibitor binding mode in which favorable interactions are formed between the benzylpiperidinone moiety and some active-site residues. The biochemical evaluation of this newly synthesized series was performed using a chemiluminescent method suitable for high-throughput screening.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available