Journal
VACCINE
Volume 20, Issue 3-4, Pages 505-515Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(01)00326-7
Keywords
influenza vaccine; liposomes; cytokines; neuraminidase
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A liposomal influenza vaccine (INFLUSOME-VAC) was developed with the objective of overcoming the major drawbacks of the currently used influenza vaccines: their relatively low efficacy in certain high-risk groups (the elderly, infants, the immunosuppressed) and the need for annual immunization. INFLUSOME-VAC consists of liposomes containing the viral surface proteins hemagglutinin (HA) and neuraminidase (NA) derived from various influenza strains and IL-2 or GM-CSF, as an adjuvant. Vaccination of mice showed that, whereas conventional vaccines induced a low- and short-term response against HA and very low or no anti-NA response, INFLUSOME-VAC produced high titers of both anti-HA and anti-NA antibodies (Abs) in young and old mice that persisted for at least 6 months. Moreover, the anti-NA Abs efficiently cross-reacted with several N2 viral subtypes spanning 20 years. and such vaccines afforded partial protection against heterosubtypic viral infection. (C) 2001 Elsevier Science Ltd. All rights reserved.
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