Journal
NEUROSCIENCE LETTERS
Volume 314, Issue 1-2, Pages 45-48Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(01)02277-7
Keywords
cerebral cholesterol; cholesterol 24S-hydroxylase; cytochrome P-450; oxysterols; Alzheimer's disease
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Funding
- NHLBI NIH HHS [HL 20948] Funding Source: Medline
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Evidence is accumulating for a link between cerebral cholesterol metabolism and Alzheimer's disease (AD). Here we focus on a possible relationship between AD and a newly discovered mechanism for cholesterol eff lux from the brain, involving conversion of brain cholesterol into 24S-hydroxycholesterol by the neuronal oxidative enzyme CYP46. There was a marked difference in the distribution of CYP46 in brains of control and AD patients. The neuronal cells were less stained in AD brains than in controls while marked positive staining was found in glial cells in AD but not in controls. The dynamic changes in the mechanisms for cholesterol efflux from the brain are of interest in relation to the link between brain cholesterol and amyloid P-protein in AD. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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