Journal
ORGANIC LETTERS
Volume 3, Issue 23, Pages 3753-3755Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol016708f
Keywords
-
Categories
Ask authors/readers for more resources
[GRAPHICS] The butane-2,3-diacetal (BDA) desymmetrized glycolic acid building block undergoes efficient and highly diastereoselective lithium enolate Michael additions to alpha,beta -unsaturated ketones, lactones, and nitro olefins. Subsequent deprotection of these Michael adducts gives a-hydroxy acids in very high yield. Hydrogenation of the nitro group in some of the adducts leads to gamma -lactams, which can be easily converted into alpha -hydroxy-gamma -amino acid derivatives.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available