Journal
BLOOD
Volume 98, Issue 10, Pages 2887-2893Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood.V98.10.2887
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The BCR-ABL oncogene is central in the pathogenesis of chronic myeloid leukemia (CML). Here, tandem nanospray mass spectrometry was used to demonstrate cell surface HLA-associated expression of the BCR-ABL peptide KQSSKALQR on class I-negative CIVIL cells transfected with HLA-A*0301, and on primary CIVIL cells from HLA-A3-positive patients. These patients mounted a cytotoxic T-lymphocyte response to KQSSKALQR that also killed autologous CML cells, and tetramer staining demonstrated the presence of circulating KQSSKALQR-specific T cells. The findings are the first demonstration that CML cells express HLA-associated leukemia-specific immunogenic peptides and provide a sound basis for immunization studies against BCR-ABL. (C) 2001 by The American Society of Hematology.
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