Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 18, Issue 1, Pages 1-12Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2015.1117452
Keywords
Isatis indigotica; antiviral activity; indole alkaloid glucoside; isatindigotindolosides A-E; Cruciferae; inhibition activity against nitric oxide production
Funding
- National Natural Sciences Foundation of China [NNSFC] [81373287, 30825044]
- Beijing Excellent Talent Training Project [2013D009008000002]
- National Science and Technology Project of China [2012ZX09301002-002, 2011ZX0 9307-002-01]
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Five new indole alkaloid glucosides named isatindigotindolosides A-E (1-5), along with three known analogs (6-8), were isolated from an aqueous extract of the Isatis indigotica roots. Their structures including the absolute configurations were determined based on comprehensive spectroscopic data analysis, combined with chemical methods and electronic circular dichroism spectra calculations. In the preliminary assays, compounds 1, 6 and 7 showed antiviral activity against influenza virus A/Hanfang/359/95 (H3N2) with IC50 values of 14.6-33.3 mu M. Compound 1 also exhibited inhibitory effect against nitric oxide (NO) production in microglial cell BV2 with an inhibition ratio of 93.0% at 10 mu M.
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