Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 184, Issue 10, Pages 1341-1344Publisher
UNIV CHICAGO PRESS
DOI: 10.1086/324002
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Funding
- NIAID NIH HHS [AI-28691, AI-27859] Funding Source: Medline
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The levels of early spliced mRNA and genomic RNA of human immunodeficiency virus (HIV) type 1 in peripheral blood mononuclear cells (PBMC) of 14 patients who were receiving highly active combination antiretroviral therapy for greater than or equal to 116 weeks were determined. The level of viral genomic RNA was below the level of detection in the plasma of these patients (<50 copies/mL), but cell-associated viral tat, rev, and nef mRNA were detected in 86% (12 of 14) of the patients. Cell-associated viral genomic RNA was detected in 57% (8 of 14) of the patients. Early viral spliced mRNA was detected in the PBMC of all patients who had positive results of testing for HIV-1 genomic RNA, and the level of viral genomic RNA in these patients was 34-2214 copies per 10(6) cells.
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