Journal
CELL
Volume 107, Issue 4, Pages 537-548Publisher
CELL PRESS
DOI: 10.1016/S0092-8674(01)00536-0
Keywords
-
Categories
Funding
- NCI NIH HHS [CA81665] Funding Source: Medline
- NCRR NIH HHS [RR11823] Funding Source: Medline
- NEI NIH HHS [R01 EY1328801] Funding Source: Medline
Ask authors/readers for more resources
Mus81, a fission yeast protein related to the XPF subunit of ERCC1-XPF nucleotide excision repair endonuclease, is essential for meiosis and important for coping with stalled replication forks. These processes require resolution of X-shaped DNA structures known as Holliday junctions. We report that Mus81 and an associated protein Eme1 are components of an endonuclease that resolves Holliday junctions into linear duplex products. Mus81 and Eme1 are required during meiosis at a late step of meiotic recombination. The mus81 meiotic defect is rescued by expression of a bacterial Holliday junction resolvase. These findings constitute strong evidence that Mus81 and Emel1 are subunits of a nuclear Holliday junction resolvase.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available