Journal
FEBS LETTERS
Volume 508, Issue 2, Pages 282-286Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(01)03078-2
Keywords
actin cytoskeleton; gelsolin; neurite outgrowth; PC12 cell; growth cone motility
Funding
- NIAMS NIH HHS [1R29AR45008-01] Funding Source: Medline
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The rational design of therapies for treating nerve injuries requires an understanding of the mechanisms underlying neurite extension. Neurite motility is driven by actin polymerization; however, the mechanisms are not clearly understood. One actin accessory protein, gelsolin, is involved with remodeling the cytoskeleton, although its role in cell motility is unclear. We report a two-fold upregulation of gelsolin upon differentiation with nerve growth factor. Cells that were genetically modified to overexpress gelsolin have longer neurites and a greater neurite motility rate compared to controls. These data suggest that gelsolin plays an important role in neurite outgrowth. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
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