Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 17, Issue 5, Pages 595-600Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2015.1042373
Keywords
antiproliferative activity; quizonaline alkaloids; (S)-vasicinone-1-O-beta-d-glucopyranoside; Peganum harmala; Zygophyllaceae
Funding
- National Natural Science Foundation of China [U1203103]
- key project of Xinjiang Production & Construction Corps Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin [BRZD1205]
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A phytochemical study on the methanol extracts from the seeds of Peganum harmala L. led to a new quizonaline alkaloid (S)-vasicinone-1-O-beta-d-glucopyranoside (1) and four known ones, (R)-vasicinone-1-O-beta-d-glucopyranoside (2), (S)-vasicinone (3), vasicine (4), and deoxyvasicinone (5). Their structures were elucidated by spectroscopic analysis including IR, HR-ESI-MS, 1D and 2D NMR, and specific rotation as well as by comparison of the data with those in the literature. All of the alkaloids were screened for antiproliferative activity against human gastric cancer cells MCG-803 with MTT method. Compounds 1 and 3 exhibited moderate inhibitory activity.
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