Journal
NEUROSCIENCE LETTERS
Volume 314, Issue 3, Pages 135-138Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(01)02299-6
Keywords
blood-brain barrier; 4-hydroxynonenal; oxidative stress; glutathione; endothelial cells; astrocytes
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The function of the blood-brain barrier (BBB) can be impaired by free radicals. Since free radicals have only a limited diffusion capacity, we tested the possibility whether one of the major secondary lipid peroxidation product - 4-hydroxynonenal, is able to influence the permeability of the BBB. Therefore, we established an in vitro BBB model and tested its capacity to degrade 4-hydroxynonenal. Although, endothelial cells and astrocytes, posses the ability to degrade 4-hydroxynonenal the aldehyde is able to increase the permeability of the BBB. Since aldehydic lipid peroxidation products are metabolized via conjugation with glutathione we proofed that a decrease in glutathione is also able to increase the permeability of the BBB. We concluded that 4-hydroxynonenal is able to impair the BBB function via the decrease of reduced glutathione. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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