Patagonicoside A:: a novel antifungal disulfated triterpene glycoside from the sea cucumber Psolus patagonicus

A new triterpene glycoside, patagonicoside A (1), has been isolated from the sea cucumber Psolus patagonicus and its structure has been elucidated by 1D and 2D NMR (H-1-, C-13-, H-1-H-1 COSY, HETCOR, COLOC and NOESY spectra), FAB-MS and chemical evidence. Compound 1 is a disulfated tetrasaccharide with a new aglycon moiety. Patagonicoside A (1) exhibits considerable antifungal activity against the pathogenic fungus Cladosporium cucumerinum. (C) 2001 Elsevier Science Ltd. All rights reserved.