Journal
SCIENCE
Volume 294, Issue 5547, Pages 1723-1726Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1062117
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Funding
- NHLBI NIH HHS [1P50-HL-54998, R37 HL036279, R01 HL064541] Funding Source: Medline
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With the draft sequence of the human genome available, there is a need to better define gene function in the context of systems biology. We studied 239 cardiovascular and renal phenotypes in 113 mate rats derived from an F-2 intercross and mapped 81 of these traits onto the genome. Aggregates of traits were identified on chromosomes 1, 2, 7, and 18. Systems biology was assessed by examining patterns of correlations (physiological profiles) that can be used for gene hunting, mechanism-based physiological studies, and, with comparative genomics, translating these data to the human genome.
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