Journal
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
Volume 158, Issue 1-2, Pages 58-64Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autneu.2010.06.002
Keywords
ATP; P2X(2/3) receptor; Myocardial pain; Nodose ganglia
Categories
Funding
- National Natural Science Foundation of China [30860086, 30860333, 30460040, 30660048]
- Ministry of Education of China [20070403007]
- Natural Science Foundation of Jiangxi Province [0640042, 2008GZY0029]
- Educational Department of Jiangxi Province [2007-60, GJJ08049]
- Jiangxi Province Excellent Ph D Students Foundation [YBP08A01]
- Innovation Foundation of Graduate School of Nanchang University [YC08B009]
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Myocardial ischemia causes the production of a variety of chemical substances which act on the cardiac afferent nerve to cause pain Myocardial damage can affect cardiac vagal afferent activity Survivors of myocardial infarction are often left with impaired activity of cardiac vagal sensory fibres The nodose ganglia (NG) are lower ganglia of cardiac vagus nerve which are chiefly visceral afferent in the sensation of heart. ATP as a possible damage signal may activate nociceptive sensory neurons Activation of P2X(3) P2X(2/3) receptors by endogenous ATP contributes to the development of hyperalgesia The present results have shown that the sensitivity of P2X(2/3) receptor in nodose ganglion neurons was Increased after myocardial ischemic injury under electrophysiological observation The inhibitive role of P2X(2/3) antagonist A-317491 on ATP-activated currents in myocardial ischemic rats was significantly increased compared with that in control group at the same concentration of A-317491 The staining of P2X(2) and P2X3 receptors in myocardial ischemic injury group appeared to be more Intense than those in naive rats and myocardial ischemic rats treated with A-317491 with immunofluorescence double labeling methods Therefore the activity of P2X(2/3) receptors in NG neurons was Involved in the transmission of myocardial ischemic nociceptive signal (C) 2010 Elsevier B V All rights reserved
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