Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 431, Issue 3, Pages 311-314Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(01)01447-9
Keywords
euteric nervous system; neuroimmune interaction; electrophysiology; thrombin receptors; trypsin
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Funding
- NIDDK NIH HHS [DK43207, DK45410, DK57840] Funding Source: Medline
- NINDS NIH HHS [NS26995] Funding Source: Medline
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The effects of proteinase-activated receptor 2 (PAR2) agonists on the electrical properties of intact guinea pig ileal myenteric neurons were measured with intracellular microelectrodes. Approximately 52% of AH neurons and 41% of S neurons responded to pressure ejection of SLIGRL-NH2 or trypsin with a prolonged depolarization that was often accompanied by increased excitability. When added to the bathing solution, trypsin caused a concentration-dependent depolarization of responding neurons with an estimated EC50 value of 87 nM. Collectively, these novel observations indicate that PAR2 excites a proportion of myenteric neurons, which may contribute to dysmotility during intestinal inflammation. (C) 2001 Elsevier Science B.V. All rights reserved.
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