Journal
FEBS LETTERS
Volume 508, Issue 3, Pages 389-393Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(01)03100-3
Keywords
antimicrobial peptide; lactoferricin; magainin; cecropin; cytoplasmic membrane; cytoplasm
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The localization of immunolabelled antimicrobial peptides was studied using transmission electron microscopy. Staphylococcus aureus and Escherichia coli were exposed to lactoferricin B (17-41), lactoferricin B (17-31) and D-lactoferricin B (17-31). E. coli was also exposed to cecropin P1 and magainin 2. The lactoferricins were found in the cytoplasm of both bacteria. In S. aureus the amount of cytoplasmic lactoferricin B (17-41) was time- and concentration-dependent, reaching a maximum within 30 min. Cecropin P1 was confined to the cell wall. while magainin 2 was found in the cytoplasm of E. coh. The finding of intracellularly localized magainin is not reported previously. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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