Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 184, Issue 1-2, Pages 1-11Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0303-7207(01)00664-5
Keywords
steroid hormone (insect); extracellular signal-regulated kinase (ERK); prothoracicotropic hormone (PTTH) phosphorylation; signal transduction; ecdysteroidogenesis
Categories
Funding
- NIDDK NIH HHS [DK-30018] Funding Source: Medline
- NIGMS NIH HHS [GM63198-01] Funding Source: Medline
Ask authors/readers for more resources
Ecdysteroid hormones are crucial in controlling the growth, molting and metamorphosis of insects. The predominant source of ecdysteroids in pre-adult insects is the prothoracic gland, which is under the acute control of the neuropeptide hormone prothoracicotropic hormone (PTTH). Previous studies using the tobacco hornworm, Manduca sexta, have shown that PTTH stimulates ecdysteroid synthesis via a series of events, including the activation of protein kinase A and the 70 kDa S6 kinase (p70(S6k)). In this study, PTTH was shown to stimulate also mitogen-activated protein kinase (MAPK) phosphorylation and activity in the Manduca prothoracic gland. The MAPK involved appears to be an extracellular signal-regulated kinase (ERK) homologue. The ERK phosphorylation inhibitors PD 98059 and UO 126 blocked basal and PTTH-stimulated ERK phosphorylation and ecdysteroid synthesis. PTTH-stimulated ERK activity may be important for both rapid regulation of ecdysteroid synthesis and for longer-term changes in the size and function of prothoracic gland cells. (C) 2001 Published by Elsevier Science Ireland Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available