4.4 Article

Optimized access to alkyl thiocyanates

Journal

TETRAHEDRON LETTERS
Volume 42, Issue 48, Pages 8479-8481

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(01)01846-9

Keywords

thiocyanates; nucleophilic substitution; trimethylsilyl; isothiocyanate

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Functionalized alkyl thiocyanates are synthesized in high yields from corresponding halides via in situ formation of tetra n-butylammonium thiocyanate. Use of this mild but efficient thiocyanation reagent limits the amounts of by-products. (C) 2001 Elsevier Science Ltd. All rights reserved.

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