Journal
ONCOGENE
Volume 20, Issue 54, Pages 7874-7887Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1204869
Keywords
HPV; E6; transformation; proteasome; PDZ domains
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The Human Papillomavirus (HPV) E6 protein is one of three oncoproteins encoded by the virus. It has long been recognized as a potent oncogene and is intimately associated with the events that result in the malignant conversion of virally infected cells. In order to understand the mechanisms by which E6 contributes to the development of human malignancy many laboratories have focused their attention on identifying the cellular proteins with which E6 interacts. In this review we discuss these interactions in the light of their respective contributions to the malignant progression of RPV transformed cells.
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