Journal
NEUROSCIENCE LETTERS
Volume 315, Issue 3, Pages 125-128Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(01)02336-9
Keywords
caspase; brain; rat; cytosol; nerve endings; nucleus; myelin
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The distribution of the caspase family (caspase-2, -3, -6, -7, -8, -9, -10) was assessed using immunochemical detection of subcellular fractions of 8-week-old rat brain tissues. The present study demonstrated that the relative protein level of caspase-2, -3, -6, -8 and -10 was highest in the soluble cytosolic fraction, while that for caspase-9 was highest in the nucleus. We also found that caspase-3 and -6 were present at high levels and caspase-2, -8 and -9 at moderate levels in the nerve endings fraction as well as in the soluble cytosolic fraction. These results suggest that rat brain caspases are differentially expressed in the subcellular fractions of the rat brain, and that caspases not only contribute to the regulation of neuronal death, but also to synaptic plasticity. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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