Journal
SCIENCE
Volume 294, Issue 5548, Pages 1933-1936Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1064081
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Funding
- NHLBI NIH HHS [5R01 HL-58770] Funding Source: Medline
- NIAID NIH HHS [5T32 AI-07290] Funding Source: Medline
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Hematopoietic stem cells (HSCs) reside predominantly in bone marrow, but low numbers of HSCs are also found in peripheral blood. We examined the fate of blood-borne HSCs using genetically marked parabiotic mice, which are surgically conjoined and share a common circulation. Parabionts rapidly established stable, functional cross engraftment of partner-derived HSCs and maintained partner-derived hematopoiesis after surgical separation. Determination of the residence time of injected blood-borne progenitor cells suggests that circulating HSCs/progenitors: are cleared quickly from the blood, These data demonstrate that HSCs rapidly and constitutively migrate through the blood and play a physiological role in, at least, the functional reengraftment of unconditioned bone marrow.
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