Journal
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
Volume 147, Issue 1-2, Pages 86-90Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autneu.2009.01.012
Keywords
Rat; Mouse; Autonomic nerve; Spleen; Colon cancer cell
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oral supplementations of L-arginine and L-lysine show tumor inhibition abilities. The splenic sympathetic nerve is involved in central modulation of cellular immunity and suppresses splenic natural killer cell activity in rats. An intravenous administration of a mixture of 10 mM L-arginine and L-lysine decreased splenic sympathetic nerve activity (splenic-SNA). We examined the effect of L-arginine and L-lysine mixtures on splenic-SNA in urethane-anesthetized rats by administration of 1 ml mixtures of 2 mM, 10 mM, and 50 MM L-arginine and L-lysine. We also studied the effect of the above mixtures on human colon cancer cell proliferation in athymic nude mice. An increase in splenic-SNA and tumor volume (2 mM), no effect (10 mM), and a decrease in both values (50 mM) were seen. Bivariate correlation analysis revealed a positive correlation between changes in splenic-SNA and tumor volume, indicating the tumor suppressing ability of weakened splenic-SNA. (c) 2009 Elsevier B.V. All rights reserved.
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