Journal
BIOMEDICAL MICRODEVICES
Volume 3, Issue 4, Pages 323-330Publisher
SPRINGER
DOI: 10.1023/A:1012412916446
Keywords
microfluidics; microelectromechanical systems; soft lithography; lab on a chip; diffusion
Funding
- NIH [HG 01642-04]
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Because microfluidic devices operate at low Reynolds number, many fluidic operations are limited by diffusion. We have developed a microfabricated rotary pump and demonstrated that active mixing can be used to overcome the slow diffusion process in two applications. First, we showed that mixing of reagents could be efficiently accomplished for objects of a wide range of diffusion constants. Second, we showed how reaction kinetics of a surface-binding assay can be enhanced by nearly two orders of magnitude.
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