Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 11, Issue 6, Pages 652-659Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-437X(00)00249-5
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Several recent studies of genome evolution indicate that the rate of DNA loss exceeds that of DNA gain, leading to an underlying mutational pressure towards collapsing the length of noncoding DNA. That such a collapse is not observed suggests opposing mechanisms favoring longer noncoding regions. The presence of transposable elements alone also does not explain observed features of noncoding DNA. At present, a multidisciplinary approach - using population genetics techniques, large-scale genomic analyses, and in silico evolution - is beginning to provide new and valuable insights into the forces that shape the length of noncoding DNA and, ultimately, genome size. Recombination, in a broad sense, might be the missing key parameter for understanding the observed variation in length of noncoding DNA in eukaryotes.
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