Journal
MOLECULAR CELL
Volume 8, Issue 6, Pages 1163-1174Publisher
CELL PRESS
DOI: 10.1016/S1097-2765(01)00419-1
Keywords
-
Categories
Ask authors/readers for more resources
The recombination mechanisms that deal with double-strand breaks in organisms as diverse as phage, bacteria, yeast, and humans are remarkably conserved. We discuss conservation in the biochemical pathways required to recombine DNA ends and in the structure of the DNA products. In addition, we highlight that two fundamentally distinct broken DNA substrates exist and describe how they are repaired differently by recombination. Finally, we discuss the need to coordinate recombinational repair with cell division through DNA damage response pathways.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available