Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 12, Issue 6, Pages 509-518Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1006/scdb.2001.0275
Keywords
LCR; opsin; Otd; photoreceptor; transcription factors
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Funding
- NEI NIH HHS [F32 EY007054] Funding Source: Medline
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Multiple cell types often differentiate from a pluripotent cell. These cells may then further diversify as distinct subtypes. The visual system provides an ideal model for studying subtype specification as various photoreceptors acquire different functions based on the type of opsin they express. Opsin expression is mostly controlled through transcriptional mechanisms that are evolutionary conserved from Drosophila to humans. In addition, it appears that, from a 'default' developmental state, distinct 'acquired' photoreceptor states develop upon receiving intrinsic or extrinsic signals. This review discusses factors involved in opsin gene regulation and how their integration may explain how subtype specificity is achieved.
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