Journal
IMMUNITY
Volume 15, Issue 6, Pages 1051-1061Publisher
CELL PRESS
DOI: 10.1016/S1074-7613(01)00252-7
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Funding
- NCI NIH HHS [R01 CA48115] Funding Source: Medline
- NIAID NIH HHS [R01 AI38903, T32 AI07313] Funding Source: Medline
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CD8 serves both as an adhesion molecule for class I MHC molecules and as a coreceptor with the TCR for T cell activation. Here we study the developmental regulation of CD8-mediated binding to noncognate peptide/MHC ligands (i.e., those not bound by the TCR). We show that CD8's ability to bind soluble class I MHC tetramers and to mediate T cell adhesion under shear flow conditions diminishes as double-positive thymocytes mature into CD8(+) T cells. Furthermore, we provide evidence that this decreased CD8 binding results from increased T cell sialylation upon T cell maturation. These data suggest that CD8's ability to interact with class I MHC is not fixed and is developmentally regulated through the T cell's glycosylation state.
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