Journal
TRENDS IN CELL BIOLOGY
Volume 11, Issue 12, Pages 492-496Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0962-8924(01)02139-0
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Many types of experiment show that the plasma membranes of cells are patchy and locally differentiated into domains. Some of these domains seem to arise through the confinement of diffusible membrane proteins. Others might arise through lipid-lipid interactions. Both types of domain are transient on a biological timescale but both could create local conditions that enhance molecular interactions, such as those that occur in receptor-mediated signaling.
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