Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 46, Issue 6, Pages 1072-1078Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.1301
Keywords
proton NMR spectroscopic imaging; 3D; MRSI; human brain; automated spectral analysis
Funding
- NINDS NIH HHS [NS38029] Funding Source: Medline
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For many clinical applications of proton MR spectroscopic imaging (MRSI) of the brain, diagnostic assessment is limited by insufficient coverage provided by single- or multislice acquisition methods as well as by the use of volume preselection methods. Additionally, traditional spectral analysis methods may limit the operator to detailed analysis of only a few selected brain regions. It is therefore highly desirable to use a fully 3D approach, combined with spectral analysis procedures that enable automated assessment of 3D metabolite distributions over the whole brain. In this study, a 3D echo-planar MRS[ technique has been implemented without volume preselection to provide sufficient spatial resolution with maximum coverage of the brain. Using MRSI acquisitions in normal subjects at 1.5T and a fully automated spectral analysis procedure, an assessment of the resultant spectral quality and the extent of viable data in human brain was carried out. The analysis found that 69% of brain voxels were obtained with acceptable spectral quality at TE = 135 ms, and 52% at TE = 25 ms. Most of the rejected voxels were located near the sinuses or temporal bones and demonstrated poor B-o homogeneity and additional regions were affected by stronger lipid contamination at TE = 25 ms. (C) 2001 Wiley-Liss, Inc.
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